Aggregation of mutant forms of Huntingtin is the underlying feature of neurodegeneration observed in Huntington's disorder. In addition to neurons, cellular processes in non-neuronal cell types are ...

Scientists named the mechanism clathrin-associated fast endosomal recycling pathway (CARP). This novel endocytic recycling pathway employed a distinct set of molecular machinery to generate the ...

The role of the adapter protein PICALM (phosphatidylinositol-binding clathrin assembly protein) in the development of Alzheimer's disease is well documented. Researchers from the German Institute ...

Stockhammer, Adarska et al. describe ARF1 compartments as the site of adaptor- and clathrin-dependent post-Golgi sorting. Shedding of ARF1 and maturation into recycling endosomes drives sorting of ...

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Impact and progress Frontiers' impact Progress Report 2022 All progress reports ...